Version 5.4
Homo sapiens Protein: NUDT10
Summary
InnateDB Protein IDBP-67346.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NUDT10
Protein Name nudix (nucleoside diphosphate linked moiety X)-type motif 10
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000348831
InnateDB Gene IDBG-67342 (NUDT10)
Protein Structure
UniProt Annotation
Function Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate.
Subcellular Localization Cytoplasm {ECO:0000305PubMed:12121577}.
Disease Associations
Tissue Specificity Mainly expressed in testis and, at lower level in brain. According to PubMed:12121577, it is widely expressed. {ECO:0000269PubMed:12105228, ECO:0000269PubMed:12121577}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008486 diphosphoinositol-polyphosphate diphosphatase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
GO:0052840 inositol diphosphate tetrakisphosphate diphosphatase activity
GO:0052843 inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity
GO:0052844 inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity
GO:0052845 inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity
GO:0052846 inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity
GO:0052847 inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity
GO:0052848 inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity
Biological Process
GO:0043647 inositol phosphate metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR000086 NUDIX hydrolase domain
IPR015797 NUDIX hydrolase domain-like
PFAM PF00293
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NFP7
PhosphoSite PhosphoSite-Q8NFP7
TrEMBL
UniProt Splice Variant
Entrez Gene 170685
UniGene Hs.375178
RefSeq XP_005262099
HUGO HGNC:17621
OMIM 300527
CCDS CCDS35278
HPRD 17651
IMGT
EMBL AF469196 AK291952 AL158055 BC049383 BC050700 CH471180
GenPept AAH49383 AAH50700 AAM64113 BAF84641 CAI40295 EAW89910 EAW89911

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca