InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZNF415

Summary

InnateDB Protein

IDBP-67363.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZNF415

Protein Name

zinc finger protein 415

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000243643

InnateDB Gene

IDBG-67361 (ZNF415)

Protein Structure

UniProt Annotation

Function

Involved in transcriptional regulation. Transcriptional activity differed among the various isoforms. All isoforms except isoform 3 seem to suppresses the transcriptional activities of AP- 1 and p53/TP53. {ECO:0000269PubMed:17055453}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:17055453}. Cytoplasm {ECO:0000269PubMed:17055453}. Note=Isoforms 1, isoform 2, isoform 4 and isoform 5 showed both nuclear and cytoplasm localization. Isoform 3 localized only to nucleus.

Disease Associations

Tissue Specificity

Expressed in all tissues examined. Isoforms are differentially expressed. Isoform 3 and isoform 5 were highly expressed, isoform 4 moderately expressed, isoform 2 lower expression, the lowest expression level was seem with isoform 1. {ECO:0000269PubMed:17055453}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0046872	metal ion binding