InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NLRP12

Summary

InnateDB Protein

IDBP-67731.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NLRP12

Protein Name

NLR family, pyrin domain containing 12

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000341428

InnateDB Gene

IDBG-67727 (NLRP12)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.

Experimentally validated
Total	26 [view]
Protein-Protein	25 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process

Biological Process

GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007165	signal transduction
GO:0008588	release of cytoplasmic sequestered NF-kappaB
GO:0009968	negative regulation of signal transduction
GO:0031953	negative regulation of protein autophosphorylation
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0045345	positive regulation of MHC class I biosynthetic process
GO:0045381	regulation of interleukin-18 biosynthetic process
GO:0045409	negative regulation of interleukin-6 biosynthetic process
GO:0045751	negative regulation of Toll signaling pathway
GO:0050710	negative regulation of cytokine secretion
GO:0050711	negative regulation of interleukin-1 secretion
GO:0050718	positive regulation of interleukin-1 beta secretion
GO:0050728	negative regulation of inflammatory response
GO:0050729	positive regulation of inflammatory response

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR003590 Leucine-rich repeat, ribonuclease inhibitor subtype
IPR004020 DAPIN domain
IPR007111 NACHT nucleoside triphosphatase
IPR011029 Death-like domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF02758

PRINTS

PIRSF

SMART

SM00368

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P59046