Version 5.4
Bos taurus Protein: ANGPT2
Summary
InnateDB Protein IDBP-679781.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ANGPT2
Protein Name Angiopoietin-2
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000014656
InnateDB Gene IDBG-628426 (ANGPT2)
Protein Structure
UniProt Annotation
Function Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating angiogenic signals mediated by ANGPT1. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal (By similarity). {ECO:0000250}.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030971 receptor tyrosine kinase binding
GO:0046872 metal ion binding
Biological Process
GO:0001525 angiogenesis
GO:0007275 multicellular organismal development
GO:0010812 negative regulation of cell-substrate adhesion
GO:0016525 negative regulation of angiogenesis
GO:0030154 cell differentiation
GO:0043537 negative regulation of blood vessel endothelial cell migration
GO:0048014 Tie signaling pathway
GO:0048514 blood vessel morphogenesis
GO:0050928 negative regulation of positive chemotaxis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID
InterPro IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
PFAM PF00147
PRINTS
PIRSF
SMART SM00186
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O77802
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 282141
UniGene Bt.137
RefSeq NP_001092325
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF032924 AF094699 BC142471
GenPept AAC62490 AAC78285 AAI42472

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca