InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: FBXW11

Summary

InnateDB Protein

IDBP-679845.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FBXW11

Protein Name

F-box and WD repeat domain containing 11

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000053291

InnateDB Gene

IDBG-628478 (FBXW11)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 66 interaction(s) predicted by orthology.

Predicted by orthology
Total	66 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0046983	protein dimerization activity

Biological Process

GO:0000209	protein polyubiquitination
GO:0006470	protein dephosphorylation
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031648	protein destabilization
GO:0042347	negative regulation of NF-kappaB import into nucleus
GO:0042753	positive regulation of circadian rhythm
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045862	positive regulation of proteolysis
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005829	cytosol
GO:0019005	SCF ubiquitin ligase complex

Protein Structure and Domains

PDB ID

InterPro

IPR001680 WD40 repeat
IPR001810 F-box domain
IPR017986 WD40-repeat-containing domain
IPR020472 G-protein beta WD-40 repeat
IPR021977 D domain of beta-TrCP

PFAM

PF00400
PF00646
PF12937
PF13013
PF12125

PRINTS

PR00320

PIRSF

SMART

SM00320
SM00256
SM01028

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt