InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: GABRA5

Summary

InnateDB Protein

IDBP-679926.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GABRA5

Protein Name

Gamma-aminobutyric acid receptor subunit alpha-5

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000004397

InnateDB Gene

IDBG-628558 (GABRA5)

Protein Structure

UniProt Annotation

Function

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. {ECO:0000250}.

Subcellular Localization

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004890	GABA-A receptor activity
GO:0005216	ion channel activity
GO:0005230	extracellular ligand-gated ion channel activity
GO:0005254	chloride channel activity
GO:0005515	protein binding

Biological Process

GO:0001662	behavioral fear response
GO:0006810	transport
GO:0006811	ion transport
GO:0006821	chloride transport
GO:0007214	gamma-aminobutyric acid signaling pathway
GO:0007605	sensory perception of sound
GO:0008306	associative learning
GO:0034220	ion transmembrane transport
GO:0043523	regulation of neuron apoptotic process
GO:0043524	negative regulation of neuron apoptotic process
GO:0048666	neuron development
GO:0060119	inner ear receptor cell development
GO:0060384	innervation
GO:0090102	cochlea development
GO:1902476	chloride transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030425	dendrite
GO:0034707	chloride channel complex
GO:0044297	cell body
GO:0045202	synapse
GO:0045211	postsynaptic membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001390 Gamma-aminobutyric-acid A receptor, alpha subunit
IPR005435 Gamma-aminobutyric-acid A receptor, alpha 5 subunit
IPR005437 Gamma-aminobutyric-acid A receptor, gamma subunit
IPR006028 Gamma-aminobutyric acid A receptor/Glycine receptor alpha
IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
IPR006201 Neurotransmitter-gated ion-channel
IPR006202 Neurotransmitter-gated ion-channel ligand-binding

PFAM

PF02932
PF02931

PRINTS

PR01079
PR01618
PR01620
PR00253
PR00252

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q08E50