InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: TLR3

Summary

InnateDB Protein

IDBP-679936.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TLR3

Protein Name

toll-like receptor 3 precursor

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000011445

InnateDB Gene

IDBG-628571 (TLR3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.

Predicted by orthology
Total	29 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003725	double-stranded RNA binding
GO:0004888	transmembrane signaling receptor activity
GO:0005515	protein binding

Biological Process

GO:0001819	positive regulation of cytokine production
GO:0002756	MyD88-independent toll-like receptor signaling pathway
GO:0006952	defense response
GO:0007165	signal transduction
GO:0007252	I-kappaB phosphorylation
GO:0009615	response to virus
GO:0032481	positive regulation of type I interferon production
GO:0032722	positive regulation of chemokine production
GO:0032728	positive regulation of interferon-beta production
GO:0032735	positive regulation of interleukin-12 production
GO:0032755	positive regulation of interleukin-6 production
GO:0032757	positive regulation of interleukin-8 production
GO:0032760	positive regulation of tumor necrosis factor production
GO:0034123	positive regulation of toll-like receptor signaling pathway
GO:0034138	toll-like receptor 3 signaling pathway
GO:0034346	positive regulation of type III interferon production
GO:0042346	positive regulation of NF-kappaB import into nucleus
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043330	response to exogenous dsRNA
GO:0045078	positive regulation of interferon-gamma biosynthetic process
GO:0045080	positive regulation of chemokine biosynthetic process
GO:0045087	innate immune response
GO:0045356	positive regulation of interferon-alpha biosynthetic process
GO:0045359	positive regulation of interferon-beta biosynthetic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046330	positive regulation of JNK cascade
GO:0050729	positive regulation of inflammatory response
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051607	defense response to virus
GO:0071260	cellular response to mechanical stimulus
GO:0097191	extrinsic apoptotic signaling pathway
GO:0097527	necroptotic signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005765	lysosomal membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
IPR000483 Cysteine-rich flanking region, C-terminal
IPR001611 Leucine-rich repeat
IPR003591 Leucine-rich repeat, typical subtype

PFAM

PF01582
PF13676
PF01463
PF00560
PF13504
PF13855

PRINTS

PIRSF

SMART

SM00255
SM00082
SM00369

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite