InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: LAX1

Summary

InnateDB Protein

IDBP-679957.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LAX1

Protein Name

Lymphocyte transmembrane adapter 1

Synonyms

LAX;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000016385

InnateDB Gene

IDBG-628589 (LAX1)

Protein Structure

UniProt Annotation

Function

Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and BCR (B-cell antigen receptor)- mediated signaling in B-cells. {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0042169	SH2 domain binding

Biological Process

GO:0000188	inactivation of MAPK activity
GO:0002376	immune system process
GO:0006955	immune response
GO:0035556	intracellular signal transduction
GO:0042113	B cell activation
GO:0046649	lymphocyte activation
GO:0048305	immunoglobulin secretion
GO:0050851	antigen receptor-mediated signaling pathway
GO:0050868	negative regulation of T cell activation

Cellular Component

GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

PFAM

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q58CT8

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

540424

UniGene

Bt.37374

RefSeq

NP_001015674

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BT021859

GenPept

AAX46706