InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: LECT1

Summary

InnateDB Protein

IDBP-679990.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LECT1

Protein Name

Leukocyte cell-derived chemotaxin 1Chondrosurfactant proteinChondromodulin-1

Synonyms

CHM-I;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000035726

InnateDB Gene

IDBG-628626 (LECT1)

Protein Structure

UniProt Annotation

Function

Bifunctional growth regulator that stimulates the growth of cultured chondrocytes in the presence of basic fibroblast growth factor (FGF) but inhibits the growth of cultured vascular endothelial cells. May contribute to the rapid growth of cartilage and vascular invasion prior to the replacement of cartilage by bone during endochondral bone development. Inhibits in vitro tube formation and mobilization of endothelial cells. Plays a role as antiangiogenic factor in cardiac valves to suppress neovascularization (By similarity). {ECO:0000250}.

Subcellular Localization

Chondromodulin-1: Secreted, extracellular space, extracellular matrix. Note=Accumulated in the inter- territorial matrix of cartilage.Chondrosurfactant protein: Endomembrane system {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Nasal and articular cartilage, and fetal epiphysis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0001886	endothelial cell morphogenesis
GO:0001937	negative regulation of endothelial cell proliferation
GO:0007275	multicellular organismal development
GO:0016525	negative regulation of angiogenesis
GO:0030154	cell differentiation
GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0051216	cartilage development

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0012505	endomembrane system
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR007084 BRICHOS domain

PFAM

PF04089

PRINTS

PIRSF

SMART

SM01039

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P17404

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

281683

UniGene

Bt.1509

RefSeq

NP_776694

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

M65081

GenPept

AAA30445