Version 5.4
Bos taurus Protein: SF3B3
Summary
InnateDB Protein IDBP-680171.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SF3B3
Protein Name Splicing factor 3B subunit 3
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000014050
InnateDB Gene IDBG-628791 (SF3B3)
Protein Structure
UniProt Annotation
Function Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 105 interaction(s) predicted by orthology.
Predicted by orthology
Total 105 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0005515 protein binding
Biological Process
GO:0006397 mRNA processing
GO:0008380 RNA splicing
Cellular Component
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005689 U12-type spliceosomal complex
GO:0071013 catalytic step 2 spliceosome
Protein Structure and Domains
PDB ID
InterPro IPR004871 Cleavage/polyadenylation specificity factor, A subunit, C-terminal
IPR017986 WD40-repeat-containing domain
PFAM PF03178
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A0JN52
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 504962
UniGene Bt.7895
RefSeq NP_001071319
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC126518
GenPept AAI26519

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca