InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: PSMB8

Summary

InnateDB Protein

IDBP-680230.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PSMB8

Protein Name

Proteasome subunit beta type-8

Synonyms

LMP7;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000003955

InnateDB Gene

IDBG-628854 (PSMB8)

Protein Structure

UniProt Annotation

Function

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides (By similarity). Required for adipocyte differentiation (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000255PROSITE- ProRule:PRU00809}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.

Predicted by orthology
Total	38 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004175	endopeptidase activity
GO:0004298	threonine-type endopeptidase activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0016787	hydrolase activity

Biological Process

GO:0002376	immune system process
GO:0006508	proteolysis
GO:0019882	antigen processing and presentation
GO:0030154	cell differentiation
GO:0045444	fat cell differentiation
GO:0051603	proteolysis involved in cellular protein catabolic process

Cellular Component

GO:0000502	proteasome complex
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005839	proteasome core complex
GO:0070062	extracellular vesicular exosome
GO:1990111	spermatoproteasome complex