InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: AARS

Summary

InnateDB Protein

IDBP-680233.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AARS

Protein Name

alanyl-tRNA synthetase, cytoplasmic

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000026393

InnateDB Gene

IDBG-628845 (AARS)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0002161	aminoacyl-tRNA editing activity
GO:0003676	nucleic acid binding
GO:0004813	alanine-tRNA ligase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008270	zinc ion binding
GO:0016876	ligase activity, forming aminoacyl-tRNA and related compounds

Biological Process

GO:0001942	hair follicle development
GO:0006400	tRNA modification
GO:0006419	alanyl-tRNA aminoacylation
GO:0006450	regulation of translational fidelity
GO:0006457	protein folding
GO:0021680	cerebellar Purkinje cell layer development
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0034620	cellular response to unfolded protein
GO:0043039	tRNA aminoacylation
GO:0043200	response to amino acid
GO:0043524	negative regulation of neuron apoptotic process
GO:0043588	skin development
GO:0050885	neuromuscular process controlling balance
GO:0050905	neuromuscular process

Cellular Component

GO:0005737	cytoplasm
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR002318 Alanine-tRNA ligase, class IIc
IPR003156 DHHA1 domain
IPR012947 Threonyl/alanyl tRNA synthetase, SAD
IPR018162 Alanine-tRNA ligase, class IIc, anti-codon-binding domain
IPR018163 Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain
IPR018164 Alanyl-tRNA synthetase, class IIc, N-terminal
IPR018165 Alanyl-tRNA synthetase, class IIc, core domain

PFAM

PF02272
PF07973
PF01411

PRINTS

PR00980

PIRSF

SMART

SM00863

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

A6QLT9

UniProt Splice Variant

Entrez Gene

510933

UniGene

Bt.44540

RefSeq

NP_001094545

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC148083 DAAA02045970 EF028073

GenPept

AAI48084 ABI97370