Version 5.4
Bos taurus Protein: PPP2CB
Summary
InnateDB Protein IDBP-680279.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPP2CB
Protein Name Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000012182
InnateDB Gene IDBG-628904 (PPP2CB)
Protein Structure
UniProt Annotation
Function PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Chromosome, centromere {ECO:0000250}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250}. Note=In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 86 interaction(s) predicted by orthology.
Predicted by orthology
Total 86 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004721 phosphoprotein phosphatase activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0008637 apoptotic mitochondrial changes
GO:0010468 regulation of gene expression
GO:0016311 dephosphorylation
GO:0034976 response to endoplasmic reticulum stress
GO:0042542 response to hydrogen peroxide
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0046677 response to antibiotic
Cellular Component
GO:0000159 protein phosphatase type 2A complex
GO:0000775 chromosome, centromeric region
GO:0000922 spindle pole
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR004843 Calcineurin-like phosphoesterase domain, apaH type
IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
IPR029052 Metallo-dependent phosphatase-like
PFAM PF00149
PRINTS PR00114
PIRSF
SMART SM00156
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q0P594
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 524361
UniGene Bt.53812
RefSeq NP_001069325
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC120332
GenPept AAI20333

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca