InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: MAPKAPK2

Summary

InnateDB Protein

IDBP-680542.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAPKAPK2

Protein Name

mitogen-activated protein kinase-activated protein kinase 2

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000015530

InnateDB Gene

IDBG-629101 (MAPKAPK2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.

Predicted by orthology
Total	38 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor

Biological Process

GO:0002224	toll-like receptor signaling pathway
GO:0006468	protein phosphorylation
GO:0006950	response to stress
GO:0006954	inflammatory response
GO:0006974	cellular response to DNA damage stimulus
GO:0009103	lipopolysaccharide biosynthetic process
GO:0018105	peptidyl-serine phosphorylation
GO:0031572	G2 DNA damage checkpoint
GO:0032496	response to lipopolysaccharide
GO:0032675	regulation of interleukin-6 production
GO:0032680	regulation of tumor necrosis factor production
GO:0034097	response to cytokine
GO:0035924	cellular response to vascular endothelial growth factor stimulus
GO:0044351	macropinocytosis
GO:0048010	vascular endothelial growth factor receptor signaling pathway
GO:0048255	mRNA stabilization
GO:0048839	inner ear development
GO:0070935	3'-UTR-mediated mRNA stabilization

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR010440 Lipopolysaccharide kinase
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF06293

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt