InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: BIRC2

Summary

InnateDB Protein

IDBP-680548.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BIRC2

Protein Name

baculoviral IAP repeat containing 2

Synonyms

BIRC2;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000046955

InnateDB Gene

IDBG-629142 (BIRC2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 111 interaction(s) predicted by orthology.

Predicted by orthology
Total	111 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0047485	protein N-terminus binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0001890	placenta development
GO:0042981	regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051726	regulation of cell cycle
GO:0060544	regulation of necroptotic process
GO:0060546	negative regulation of necroptotic process
GO:0070266	necroptotic process
GO:1902443	negative regulation of ripoptosome assembly involved in necroptotic process
GO:1902523	positive regulation of protein K63-linked ubiquitination
GO:1902524	positive regulation of protein K48-linked ubiquitination
GO:1902527	positive regulation of protein monoubiquitination
GO:2000377	regulation of reactive oxygen species metabolic process

Cellular Component

GO:0005634	nucleus
GO:0009898	cytoplasmic side of plasma membrane
GO:0035631	CD40 receptor complex

Protein Structure and Domains

PDB ID

InterPro

IPR001315 CARD domain
IPR001370 Baculoviral inhibition of apoptosis protein repeat
IPR001841 Zinc finger, RING-type
IPR011029 Death-like domain

PFAM

PF00619
PF00653
PF13639
PF14634

PRINTS

PIRSF

SMART

SM00114
SM00238
SM00184

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

539314

UniGene

RefSeq

XP_005215803

HUGO

HGNC:590

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept