Version 5.4
Bos taurus Protein: TMEM100
Summary
InnateDB Protein IDBP-680601.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TMEM100
Protein Name Transmembrane protein 100
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000012241
InnateDB Gene IDBG-629208 (TMEM100)
Protein Structure
UniProt Annotation
Function Plays a role during embryonic arterial endothelium differentiation and vascular morphogenesis through the ACVRL1 receptor-dependent signaling pathway upon stimulation by bone morphogenetic proteins, such as GDF2/BMP9 and BMP10. {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Perikaryon {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Note=Colocalized with HSPA5 in the endoplasmic reticulum (ER). Enriched in ER microsome. Colocalized with BMP4 in neural cell bodies and neural fibers of the enteric nervous system (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0001525 angiogenesis
GO:0001570 vasculogenesis
GO:0001701 in utero embryonic development
GO:0007219 Notch signaling pathway
GO:0007275 multicellular organismal development
GO:0030154 cell differentiation
GO:0030509 BMP signaling pathway
GO:0043491 protein kinase B signaling
GO:0045603 positive regulation of endothelial cell differentiation
GO:0060842 arterial endothelial cell differentiation
GO:0071773 cellular response to BMP stimulus
GO:2001214 positive regulation of vasculogenesis
Cellular Component
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043204 perikaryon
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q2KIC8
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 613987
UniGene Bt.1787
RefSeq NP_001039987
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC112685
GenPept AAI12686

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca