Version 5.4
Bos taurus Protein: YOD1
Summary
InnateDB Protein IDBP-680628.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol YOD1
Protein Name Ubiquitin thioesterase OTU1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000027017
InnateDB Gene IDBG-629234 (YOD1)
Protein Structure
UniProt Annotation
Function Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains. Cleaves both polyubiquitin and di-ubiquitin (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004843 ubiquitin-specific protease activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
GO:1990380 Lys48-specific deubiquitinase activity
Biological Process
GO:0006508 proteolysis
GO:0006520 cellular amino acid metabolic process
GO:0006986 response to unfolded protein
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0035523 protein K29-linked deubiquitination
GO:0035871 protein K11-linked deubiquitination
GO:0070536 protein K63-linked deubiquitination
GO:0071108 protein K48-linked deubiquitination
GO:1990167 protein K27-linked deubiquitination
GO:1990168 protein K33-linked deubiquitination
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR003323 Ovarian tumour, otubain
IPR029071 Ubiquitin-related domain
PFAM PF02338
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q05B57
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 539931
UniGene Bt.52189
RefSeq NP_001073778
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC122788
GenPept AAI22789

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca