Version 5.4
Bos taurus Protein: FGFR1
Summary
InnateDB Protein IDBP-680681.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FGFR1
Protein Name fibroblast growth factor receptor 1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000020550
InnateDB Gene IDBG-629273 (FGFR1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.
Predicted by orthology
Total 36 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005007 fibroblast growth factor-activated receptor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008201 heparin binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0017134 fibroblast growth factor binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001525 angiogenesis
GO:0001657 ureteric bud development
GO:0001701 in utero embryonic development
GO:0001759 organ induction
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0002062 chondrocyte differentiation
GO:0006468 protein phosphorylation
GO:0007420 brain development
GO:0007435 salivary gland morphogenesis
GO:0007605 sensory perception of sound
GO:0008284 positive regulation of cell proliferation
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0010468 regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010863 positive regulation of phospholipase C activity
GO:0010976 positive regulation of neuron projection development
GO:0016310 phosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0021769 orbitofrontal cortex development
GO:0021847 ventricular zone neuroblast division
GO:0030324 lung development
GO:0030326 embryonic limb morphogenesis
GO:0030901 midbrain development
GO:0035607 fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development
GO:0042127 regulation of cell proliferation
GO:0042472 inner ear morphogenesis
GO:0042473 outer ear morphogenesis
GO:0042474 middle ear morphogenesis
GO:0043406 positive regulation of MAP kinase activity
GO:0043410 positive regulation of MAPK cascade
GO:0045666 positive regulation of neuron differentiation
GO:0045787 positive regulation of cell cycle
GO:0046777 protein autophosphorylation
GO:0048339 paraxial mesoderm development
GO:0048378 regulation of lateral mesodermal cell fate specification
GO:0048469 cell maturation
GO:0048514 blood vessel morphogenesis
GO:0048699 generation of neurons
GO:0048762 mesenchymal cell differentiation
GO:0060045 positive regulation of cardiac muscle cell proliferation
GO:0060117 auditory receptor cell development
GO:0060445 branching involved in salivary gland morphogenesis
GO:0060484 lung-associated mesenchyme development
GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
GO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
GO:2001239 regulation of extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043235 receptor complex
Protein Structure and Domains
PDB ID
InterPro IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR011009 Protein kinase-like domain
IPR013098 Immunoglobulin I-set
IPR013151 Immunoglobulin
IPR016248 Fibroblast growth factor receptor family
IPR020635 Tyrosine-protein kinase, catalytic domain
PFAM PF00069
PF07714
PF07679
PF00047
PRINTS PR00109
PIRSF PIRSF000628
SMART SM00220
SM00408
SM00409
SM00219
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL A4IFL5
UniProt Splice Variant
Entrez Gene 281768
UniGene Bt.32941
RefSeq NP_001103677
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC134637 DAAA02060851 DAAA02060852
GenPept AAI34638

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca