Version 5.4
Bos taurus Protein: DNA2
Summary
InnateDB Protein IDBP-680684.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DNA2
Protein Name DNA replication helicase 2 homolog (yeast)
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000003395
InnateDB Gene IDBG-629278 (DNA2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003824 catalytic activity
GO:0004386 helicase activity
GO:0004518 nuclease activity
GO:0004519 endonuclease activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016890 site-specific endodeoxyribonuclease activity, specific for altered base
GO:0017108 5'-flap endonuclease activity
GO:0043139 5'-3' DNA helicase activity
GO:0043142 single-stranded DNA-dependent ATPase activity
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0000076 DNA replication checkpoint
GO:0000729 DNA double-strand break processing
GO:0000737 DNA catabolic process, endonucleolytic
GO:0006200 ATP catabolic process
GO:0006260 DNA replication
GO:0006264 mitochondrial DNA replication
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0006974 cellular response to DNA damage stimulus
GO:0008152 metabolic process
GO:0032508 DNA duplex unwinding
GO:0033567 DNA replication, Okazaki fragment processing
GO:0043137 DNA replication, removal of RNA primer
GO:0043504 mitochondrial DNA repair
GO:0045740 positive regulation of DNA replication
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005760 gamma DNA polymerase complex
GO:0042645 mitochondrial nucleoid
Protein Structure and Domains
PDB ID
InterPro IPR014808 DNA replication factor Dna2, N-terminal
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF08696
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt E1BMP7
PhosphoSite PhosphoSite-
TrEMBL K7DXW3
UniProt Splice Variant
Entrez Gene 540969
UniGene Bt.62867
RefSeq NP_001179731
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02061817
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca