Version 5.4
Bos taurus Protein: PLEKHA2
Summary
InnateDB Protein IDBP-680756.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLEKHA2
Protein Name Pleckstrin homology domain-containing family A member 2
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000031440
InnateDB Gene IDBG-629347 (PLEKHA2)
Protein Structure
UniProt Annotation
Function Binds specifically to phosphatidylinositol 3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Note=Locates to the plasma membrane after treatments that stimulate the production of PtdIns3,4P2. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005545 1-phosphatidylinositol binding
GO:0008289 lipid binding
GO:0030165 PDZ domain binding
Biological Process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR001849 Pleckstrin homology domain
PFAM PF00169
PRINTS
PIRSF
SMART SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3ZBA3
PhosphoSite PhosphoSite-
TrEMBL F1MHG9
UniProt Splice Variant
Entrez Gene 530879
UniGene Bt.22283
RefSeq NP_001030460
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC103474 DAAA02060866
GenPept AAI03475

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca