InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: NEIL2

Summary

InnateDB Protein

IDBP-680820.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NEIL2

Protein Name

Endonuclease 8-like 2

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000006262

InnateDB Gene

IDBG-629418 (NEIL2)

Protein Structure

UniProt Annotation

Function

Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003684	damaged DNA binding
GO:0003824	catalytic activity
GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity
GO:0008017	microtubule binding
GO:0008270	zinc ion binding
GO:0016787	hydrolase activity
GO:0016798	hydrolase activity, acting on glycosyl bonds
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0016829	lyase activity
GO:0046872	metal ion binding

Biological Process

GO:0000737	DNA catabolic process, endonucleolytic
GO:0006281	DNA repair
GO:0006284	base-excision repair
GO:0006289	nucleotide-excision repair
GO:0006974	cellular response to DNA damage stimulus
GO:0008152	metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005876	spindle microtubule
GO:0015630	microtubule cytoskeleton

Protein Structure and Domains

PDB ID

InterPro

IPR000214 Zinc finger, DNA glycosylase/AP lyase-type
IPR010979 Ribosomal protein S13-like, H2TH
IPR012319 DNA glycosylase/AP lyase, catalytic domain
IPR015886 DNA glycosylase/AP lyase, H2TH DNA-binding

PFAM

PF01149
PF06831

PRINTS

PIRSF

SMART

SM00898

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q6IE77