Version 5.4
Bos taurus Protein: SPDEF
Summary
InnateDB Protein IDBP-680913.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPDEF
Protein Name SAM pointed domain-containing Ets transcription factor
Synonyms pdef;
Species Bos taurus
Ensembl Protein ENSBTAP00000029329
InnateDB Gene IDBG-629506 (SPDEF)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0010454 negative regulation of cell fate commitment
GO:0010455 positive regulation of cell fate commitment
GO:0030154 cell differentiation
GO:0043065 positive regulation of apoptotic process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0060480 lung goblet cell differentiation
GO:0060576 intestinal epithelial cell development
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR000418 Ets domain
IPR003118 Pointed domain
IPR013761 Sterile alpha motif/pointed domain
PFAM PF00178
PF02198
PRINTS PR00454
PIRSF
SMART SM00413
SM00251
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q5EM58
UniProt Splice Variant
Entrez Gene 497620
UniGene Bt.29333
RefSeq NP_001075047
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AY862876 BC133366 DAAA02054926
GenPept AAI33367 AAW81979

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca