InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: TACR2

Summary

InnateDB Protein

IDBP-680937.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TACR2

Protein Name

Substance-K receptor

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000028870

InnateDB Gene

IDBG-629530 (TACR2)

Protein Structure

UniProt Annotation

Function

This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0004930	G-protein coupled receptor activity
GO:0004995	tachykinin receptor activity
GO:0005515	protein binding

Biological Process

GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007217	tachykinin receptor signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000611 Neuropeptide Y receptor family
IPR000913 Neurokinin NK2 receptor
IPR001681 Neurokinin receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR01012
PR01025
PR00244

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P05363