InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: MPZL1

Summary

InnateDB Protein

IDBP-680949.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MPZL1

Protein Name

Myelin protein zero-like protein 1

Synonyms

PZR;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000003653

InnateDB Gene

IDBG-629543 (MPZL1)

Protein Structure

UniProt Annotation

Function

Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine- protein kinases. May be involved in regulation of integrin- mediated cell motility (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

Cellular Component

GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000920 Myelin P0 protein like
IPR003596 Immunoglobulin V-set, subgroup
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013106 Immunoglobulin V-set domain

PFAM

PF07686

PRINTS

PR00213

PIRSF

SMART

SM00406
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q32PI9

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

539387

UniGene

Bt.56060

RefSeq

NP_001069626

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC108099 DQ375557

GenPept

AAI08100 ABD42945