Bos taurus Protein: BT.85254
InnateDB Protein IDBP-681042.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.85254
Protein Name secreted frizzled-related protein 1 precursor
Species Bos taurus
Ensembl Protein ENSBTAP00000039575
InnateDB Gene IDBG-629640 (BT.85254)
Protein Structure
UniProt Annotation
Subcellular Localization
Disease Associations
Tissue Specificity
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004197 cysteine-type endopeptidase activity
GO:0005109 frizzled binding
GO:0005515 protein binding
GO:0008144 drug binding
GO:0008201 heparin binding
GO:0017147 Wnt-protein binding
GO:0042802 identical protein binding
Biological Process
GO:0001649 osteoblast differentiation
GO:0001657 ureteric bud development
GO:0001756 somitogenesis
GO:0001843 neural tube closure
GO:0002244 hematopoietic progenitor cell differentiation
GO:0006508 proteolysis
GO:0007275 multicellular organismal development
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0008584 male gonad development
GO:0008585 female gonad development
GO:0009267 cellular response to starvation
GO:0009950 dorsal/ventral axis specification
GO:0009952 anterior/posterior pattern specification
GO:0010564 regulation of cell cycle process
GO:0010629 negative regulation of gene expression
GO:0010719 negative regulation of epithelial to mesenchymal transition
GO:0014034 neural crest cell fate commitment
GO:0014070 response to organic cyclic compound
GO:0016055 Wnt signaling pathway
GO:0021915 neural tube development
GO:0022601 menstrual cycle phase
GO:0030097 hemopoiesis
GO:0030177 positive regulation of Wnt signaling pathway
GO:0030178 negative regulation of Wnt signaling pathway
GO:0030279 negative regulation of ossification
GO:0030307 positive regulation of cell growth
GO:0030308 negative regulation of cell growth
GO:0030336 negative regulation of cell migration
GO:0030514 negative regulation of BMP signaling pathway
GO:0033689 negative regulation of osteoblast proliferation
GO:0035019 somatic stem cell maintenance
GO:0042493 response to drug
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043508 negative regulation of JUN kinase activity
GO:0044344 cellular response to fibroblast growth factor stimulus
GO:0044345 stromal-epithelial cell signaling involved in prostate gland development
GO:0045578 negative regulation of B cell differentiation
GO:0045600 positive regulation of fat cell differentiation
GO:0045668 negative regulation of osteoblast differentiation
GO:0045671 negative regulation of osteoclast differentiation
GO:0045880 positive regulation of smoothened signaling pathway
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046546 development of primary male sexual characteristics
GO:0046676 negative regulation of insulin secretion
GO:0046851 negative regulation of bone remodeling
GO:0048147 negative regulation of fibroblast proliferation
GO:0048546 digestive tract morphogenesis
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation
GO:0060070 canonical Wnt signaling pathway
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0060218 hematopoietic stem cell differentiation
GO:0060346 bone trabecula formation
GO:0060527 prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060687 regulation of branching involved in prostate gland morphogenesis
GO:0060766 negative regulation of androgen receptor signaling pathway
GO:0071305 cellular response to vitamin D
GO:0071347 cellular response to interleukin-1
GO:0071356 cellular response to tumor necrosis factor
GO:0071363 cellular response to growth factor stimulus
GO:0071380 cellular response to prostaglandin E stimulus
GO:0071391 cellular response to estrogen stimulus
GO:0071392 cellular response to estradiol stimulus
GO:0071456 cellular response to hypoxia
GO:0071481 cellular response to X-ray
GO:0071504 cellular response to heparin
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0071773 cellular response to BMP stimulus
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090175 regulation of establishment of planar polarity
GO:0090179 planar cell polarity pathway involved in neural tube closure
GO:0090244 Wnt signaling pathway involved in somitogenesis
GO:0090246 convergent extension involved in somitogenesis
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000041 negative regulation of planar cell polarity pathway involved in axis elongation
GO:2000052 positive regulation of non-canonical Wnt signaling pathway
GO:2000054 negative regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification
GO:2000080 negative regulation of canonical Wnt receptor signaling pathway involved in controlling type B pancreatic cell proliferation
GO:2000270 negative regulation of fibroblast apoptotic process
GO:2000271 positive regulation of fibroblast apoptotic process
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
GO:0005622 intracellular
GO:0005829 cytosol
GO:0009986 cell surface
GO:0031012 extracellular matrix
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
InterPro IPR001134 Netrin domain
IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
IPR018933 Netrin module, non-TIMP type
IPR020067 Frizzled domain
PFAM PF01759
Post-translational Modifications
PhosphoSite PhosphoSite-
UniProt Splice Variant
Entrez Gene 282068
UniGene Bt.85254
RefSeq NP_776885
EMBL DAAA02060928