Version 5.4
Bos taurus Protein: ELP3
Summary
InnateDB Protein IDBP-681087.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ELP3
Protein Name Elongator complex protein 3
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000003541
InnateDB Gene IDBG-629659 (ELP3)
Protein Structure
UniProt Annotation
Function Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. May also have a methyltransferase activity. Involved in cell migration (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0004402 histone acetyltransferase activity
GO:0005515 protein binding
GO:0008080 N-acetyltransferase activity
GO:0008607 phosphorylase kinase regulator activity
GO:0016740 transferase activity
GO:0016746 transferase activity, transferring acyl groups
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006368 transcription elongation from RNA polymerase II promoter
GO:0016573 histone acetylation
GO:0030335 positive regulation of cell migration
GO:0045859 regulation of protein kinase activity
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0008023 transcription elongation factor complex
GO:0016591 DNA-directed RNA polymerase II, holoenzyme
GO:0033588 Elongator holoenzyme complex
Protein Structure and Domains
PDB ID
InterPro IPR000182 GNAT domain
IPR005910 Histone acetyltransferase ELP3
IPR006638 Elongator protein 3/MiaB/NifB
IPR007197 Radical SAM
IPR016181 Acyl-CoA N-acyltransferase
PFAM PF00583
PF13302
PF13508
PF13673
PF13718
PF04055
PRINTS
PIRSF PIRSF005669
SMART SM00729
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q2KJ61
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 784720
UniGene Bt.4295
RefSeq NP_001124234
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC105500
GenPept AAI05501

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca