Version 5.4
Bos taurus Protein: TMEM106B
Summary
InnateDB Protein IDBP-681100.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TMEM106B
Protein Name Transmembrane protein 106B
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000026319
InnateDB Gene IDBG-629677 (TMEM106B)
Protein Structure
UniProt Annotation
Function Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with MAP6. May act by inhibiting retrograde transport of lysosomes along dendrites. Required for dendrite branching (By similarity). {ECO:0000250}.
Subcellular Localization Late endosome membrane {ECO:0000250}; Single-pass type II membrane protein. Lysosome membrane {ECO:0000250}; Single-pass type II membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006810 transport
GO:0032418 lysosome localization
GO:0048813 dendrite morphogenesis
Cellular Component
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005768 endosome
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031902 late endosome membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR009790 Protein of unknown function DUF1356, TMEM106
PFAM PF07092
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3ZC25
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 508903
UniGene Bt.49435
RefSeq NP_001029509
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC102965
GenPept AAI02966

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca