Version 5.4
Bos taurus Protein: ARL4A
Summary
InnateDB Protein IDBP-681143.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARL4A
Protein Name ADP-ribosylation factor-like protein 4A
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000003722
InnateDB Gene IDBG-629726 (ARL4A)
Protein Structure
UniProt Annotation
Function Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}. Cytoplasm {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Note=Localization in the nucleolus is dependent by nucleotide binding. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
Biological Process
GO:0006184 GTP catabolic process
GO:0006886 intracellular protein transport
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0015031 protein transport
GO:0050873 brown fat cell differentiation
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR000795 Elongation factor, GTP-binding domain
IPR001806 Small GTPase superfamily
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR006687 Small GTPase superfamily, SAR1-type
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR006762 Gtr1/RagA G protein
IPR013684 Mitochondrial Rho-like
IPR019009 Signal recognition particle receptor, beta subunit
IPR020849 Small GTPase superfamily, Ras type
IPR024156 Small GTPase superfamily, ARF type
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00009
PF00071
PF00025
PF04670
PF08477
PF09439
PRINTS PR00315
PR00449
PR00328
PIRSF
SMART SM00175
SM00178
SM00173
SM00177
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3T0M9
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 767906
UniGene Bt.7170
RefSeq NP_001070453
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC102325
GenPept AAI02326

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca