InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: CLGN

Summary

InnateDB Protein

IDBP-681148.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CLGN

Protein Name

Calmegin

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000002071

InnateDB Gene

IDBG-629717 (CLGN)

Protein Structure

UniProt Annotation

Function

Functions during spermatogenesis as a chaperone for a range of client proteins that are important for sperm adhesion onto the egg zona pellucida and for subsequent penetration of the zona pellucida. Required for normal sperm migration from the uterus into the oviduct. Required for normal male fertility. Binds calcium ions (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0044183	protein binding involved in protein folding
GO:0051082	unfolded protein binding

Biological Process

GO:0006457	protein folding
GO:0006461	protein complex assembly
GO:0007338	single fertilization
GO:0007339	binding of sperm to zona pellucida

Cellular Component

GO:0005635	nuclear envelope
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane