Version 5.4
Bos taurus Protein: VMP1
Summary
InnateDB Protein IDBP-681196.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VMP1
Protein Name Vacuole membrane protein 1
Synonyms TMEM49;
Species Bos taurus
Ensembl Protein ENSBTAP00000015439
InnateDB Gene IDBG-629778 (VMP1)
Protein Structure
UniProt Annotation
Function Stress-induced protein that, when overexpressed, promotes formation of intracellular vacuoles followed by cell death. May be involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis. Involved in cell-cell adhesion. Plays an essential role in formation of cell junctions. Plays a role in the initial stages of the autophagic process through its interaction with BECN1 (By similarity). {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Vacuole membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006914 autophagy
GO:0007155 cell adhesion
GO:0007566 embryo implantation
GO:0010506 regulation of autophagy
GO:0016337 single organismal cell-cell adhesion
GO:0034329 cell junction assembly
Cellular Component
GO:0000407 pre-autophagosomal structure
GO:0000421 autophagic vacuole membrane
GO:0005773 vacuole
GO:0005774 vacuolar membrane
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q0VCK9
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 508631
UniGene Bt.111400
RefSeq NP_001068836
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC120116
GenPept AAI20117

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca