InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: MGARP

Summary

InnateDB Protein

IDBP-681223.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MGARP

Protein Name

Uncharacterized protein C4orf49 homolog

Synonyms

C17H4orf49; CESP-1; OSAP;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000045413

InnateDB Gene

IDBG-629802 (MGARP)

Protein Structure

UniProt Annotation

Function

Plays a role in the trafficking of mitochondria along microtubules. Regulates the kinesin-mediated axonal transport of mitochondria to nerve terminals along microtubules during hypoxia. Participates in the translocation of TRAK2/GRIF1 from the cytoplasm to the mitochondrion. Also plays a role in steroidogenesis through maintenance of mitochondrial abundance and morphology (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Mitochondrion. Mitochondrion outer membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Colocalizes with RHOT1, RHOT2, TRAK1 and TRAK2 at the mitochondrion. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006626	protein targeting to mitochondrion
GO:0008089	anterograde axon cargo transport
GO:0008090	retrograde axon cargo transport
GO:0010822	positive regulation of mitochondrion organization
GO:0019896	axon transport of mitochondrion
GO:0071383	cellular response to steroid hormone stimulus
GO:0071456	cellular response to hypoxia
GO:0097211	cellular response to gonadotropin-releasing hormone

Cellular Component

GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031307	integral component of mitochondrial outer membrane

Protein Structure and Domains

PDB ID

InterPro

PFAM

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

A6QLZ1

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

513234

UniGene

Bt.25070

RefSeq

NP_001160083

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC148137

GenPept

AAI48138