Version 5.4
Bos taurus Protein: POLB
Summary
InnateDB Protein IDBP-681276.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol POLB
Protein Name DNA polymerase beta
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000000276
InnateDB Gene IDBG-629853 (POLB)
Protein Structure
UniProt Annotation
Function Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Cytoplasmic in normal conditions. Translocates to the nucleus following DNA damage (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0003887 DNA-directed DNA polymerase activity
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0016740 transferase activity
GO:0016779 nucleotidyltransferase activity
GO:0016829 lyase activity
GO:0019899 enzyme binding
GO:0034061 DNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-dependent DNA replication
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0006974 cellular response to DNA damage stimulus
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0051402 neuron apoptotic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005874 microtubule
GO:0005876 spindle microtubule
Protein Structure and Domains
PDB ID
InterPro IPR002008 DNA polymerase family X, beta-like
IPR002054 DNA-directed DNA polymerase X
IPR003583 Helix-hairpin-helix DNA-binding motif, class 1
IPR010996 DNA polymerase beta-like, N-terminal domain
IPR018944 DNA polymerase lambda, fingers domain
IPR022312 DNA polymerase family X
PFAM PF10391
PRINTS PR00870
PR00869
PIRSF
SMART SM00483
SM00278
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q27958
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 614688
UniGene Bt.19548
RefSeq NP_001029936
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC103229 S80341
GenPept AAD14333 AAI03230

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca