Version 5.4
Bos taurus Protein: PRKAA1
Summary
InnateDB Protein IDBP-681350.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRKAA1
Protein Name 5'-AMP-activated protein kinase catalytic subunit alpha-1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000000017
InnateDB Gene IDBG-629895 (PRKAA1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 78 interaction(s) predicted by orthology.
Predicted by orthology
Total 78 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003682 chromatin binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004679 AMP-activated protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0035174 histone serine kinase activity
Biological Process
GO:0000187 activation of MAPK activity
GO:0006006 glucose metabolic process
GO:0006468 protein phosphorylation
GO:0008610 lipid biosynthetic process
GO:0009411 response to UV
GO:0010332 response to gamma radiation
GO:0010508 positive regulation of autophagy
GO:0010628 positive regulation of gene expression
GO:0016310 phosphorylation
GO:0019395 fatty acid oxidation
GO:0031669 cellular response to nutrient levels
GO:0032007 negative regulation of TOR signaling
GO:0035404 histone-serine phosphorylation
GO:0042149 cellular response to glucose starvation
GO:0042542 response to hydrogen peroxide
GO:0042593 glucose homeostasis
GO:0042752 regulation of circadian rhythm
GO:0043066 negative regulation of apoptotic process
GO:0050995 negative regulation of lipid catabolic process
GO:1901563 response to camptothecin
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0031588 AMP-activated protein kinase complex
Protein Structure and Domains
PDB ID
InterPro IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR028375 KA1 domain/Ssp2 C-terminal domain
PFAM PF00069
PF07714
PRINTS PR00109
PIRSF
SMART SM00220
SM00219
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL F1MBG5
UniProt Splice Variant
Entrez Gene 540404
UniGene Bt.42875
RefSeq XP_005221613
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC153842 DAAA02050552
GenPept AAI53843

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca