Version 5.4
Bos taurus Protein: C9
Summary
InnateDB Protein IDBP-681370.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol C9
Protein Name Complement component C9
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000021495
InnateDB Gene IDBG-629942 (C9)
Protein Structure
UniProt Annotation
Function Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC (By similarity). {ECO:0000250}.
Subcellular Localization Secreted {ECO:0000250}. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Secreted as soluble monomer. Oligomerizes at target membranes, forming a pre-pore. A conformation change then leads to the formation of a 100 Angstrom diameter pore (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0002376 immune system process
GO:0006955 immune response
GO:0006957 complement activation, alternative pathway
GO:0006958 complement activation, classical pathway
GO:0019835 cytolysis
GO:0045087 innate immune response
Cellular Component
GO:0005576 extracellular region
GO:0005579 membrane attack complex
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Protein Structure and Domains
PDB ID
InterPro IPR000884 Thrombospondin, type 1 repeat
IPR001862 Membrane attack complex component/perforin/complement C9
IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
IPR020864 Membrane attack complex component/perforin (MACPF) domain
PFAM PF00090
PF00057
PF01823
PRINTS PR00764
PR00261
PIRSF
SMART SM00209
SM00192
SM00457
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3MHN2
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 526766
UniGene Bt.14139
RefSeq NP_001030441
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC105174
GenPept AAI05175

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca