Version 5.4
Bos taurus Protein: DUSP10
Summary
InnateDB Protein IDBP-681712.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DUSP10
Protein Name Dual specificity protein phosphatase 10
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000002265
InnateDB Gene IDBG-630272 (DUSP10)
Protein Structure
UniProt Annotation
Function Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004721 phosphoprotein phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0016787 hydrolase activity
GO:0016791 phosphatase activity
GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity
GO:0033549 MAP kinase phosphatase activity
Biological Process
GO:0000188 inactivation of MAPK activity
GO:0002819 regulation of adaptive immune response
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation
GO:0032496 response to lipopolysaccharide
GO:0032873 negative regulation of stress-activated MAPK cascade
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0043508 negative regulation of JUN kinase activity
GO:0045088 regulation of innate immune response
GO:0046329 negative regulation of JNK cascade
GO:0048709 oligodendrocyte differentiation
GO:0060266 negative regulation of respiratory burst involved in inflammatory response
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
Protein Structure and Domains
PDB ID
InterPro IPR000340 Dual specificity phosphatase, catalytic domain
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR001763 Rhodanese-like domain
IPR008343 Mitogen-activated protein (MAP) kinase phosphatase
IPR020417 Atypical dual specificity phosphatase
IPR020422 Dual specificity phosphatase, subgroup, catalytic domain
IPR029021 Protein-tyrosine phosphatase-like
PFAM PF00782
PF00581
PRINTS PR01764
PR01908
PIRSF PIRSF000939
SMART SM00450
SM00195
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q0IID7
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 541175
UniGene Bt.68697
RefSeq NP_001029897
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC122694
GenPept AAI22695

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca