Version 5.4
Bos taurus Protein: MESDC2
Summary
InnateDB Protein IDBP-681741.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MESDC2
Protein Name LDLR chaperone MESD
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000002045
InnateDB Gene IDBG-630297 (MESDC2)
Protein Structure
UniProt Annotation
Function Chaperone specifically assisting the folding of beta- propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction (By similarity). {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum {ECO:0000255PROSITE- ProRule:PRU10138}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0050750 low-density lipoprotein particle receptor binding
Biological Process
GO:0006457 protein folding
GO:0016055 Wnt signaling pathway
GO:0034394 protein localization to cell surface
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR019330 Mesoderm development candidate 2
PFAM PF10185
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3T0U1
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 514610
UniGene Bt.69376
RefSeq NP_001029641
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC102262
GenPept AAI02263

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca