InnateDB Protein
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IDBP-681761.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ATP5J
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Protein Name
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ATP synthase-coupling factor 6, mitochondrial
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Synonyms
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000054675
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InnateDB Gene
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IDBG-630313 (ATP5J)
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Protein Structure
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Function |
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes.
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Subcellular Localization |
Mitochondrion. Mitochondrion inner membrane.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
9 [view]
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Molecular Function |
Accession |
GO Term |
GO:0015078
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hydrogen ion transmembrane transporter activity
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Biological Process |
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Cellular Component |
GO:0000276
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mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
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GO:0005739
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mitochondrion
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GO:0005743
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mitochondrial inner membrane
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GO:0005753
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mitochondrial proton-transporting ATP synthase complex
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GO:0016020
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membrane
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GO:0045263
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proton-transporting ATP synthase complex, coupling factor F(o)
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PDB ID |
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InterPro |
IPR008387
ATPase, F0 complex, subunit F6, mitochondrial
IPR016349
ATPase, F0 complex, subunit F6, mitochondrial subgroup
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PFAM |
PF05511
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PRINTS |
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PIRSF |
PIRSF002455
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P02721
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
282690
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UniGene |
Bt.404
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RefSeq |
XP_005201201
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HUGO |
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
BC103429
M19217
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GenPept |
AAA30511
AAI03430
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