InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: IL18

Summary

InnateDB Protein

IDBP-681950.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL18

Protein Name

Interleukin-18

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000055793

InnateDB Gene

IDBG-630481 (IL18)

Protein Structure

UniProt Annotation

Function

Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells. {ECO:0000250}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity

Biological Process

GO:0000165	MAPK cascade
GO:0001525	angiogenesis
GO:0006954	inflammatory response
GO:0010628	positive regulation of gene expression
GO:0030101	natural killer cell activation
GO:0030155	regulation of cell adhesion
GO:0031663	lipopolysaccharide-mediated signaling pathway
GO:0032725	positive regulation of granulocyte macrophage colony-stimulating factor production
GO:0032729	positive regulation of interferon-gamma production
GO:0032740	positive regulation of interleukin-17 production
GO:0032819	positive regulation of natural killer cell proliferation
GO:0042088	T-helper 1 type immune response
GO:0042104	positive regulation of activated T cell proliferation
GO:0042346	positive regulation of NF-kappaB import into nucleus
GO:0051142	positive regulation of NK T cell proliferation
GO:0071407	cellular response to organic cyclic compound

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000975 Interleukin-1 family
IPR008996 Cytokine, IL-1-like
IPR015529 Interleukin-18

PFAM

PF00340

PRINTS

PR00264
PR01933

PIRSF

PIRSF015162

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9TU73

PhosphoSite

PhosphoSite-

TrEMBL

Q9MZL8

UniProt Splice Variant

Entrez Gene

281249

UniGene

Bt.234

RefSeq

NP_776516

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AF124789 AF173175 BC102879 EU276078 EU574909 GJ062397

GenPept

AAF08686 AAF89833 AAI02880 ABX72076 ACC60256 DAA22357