Version 5.4
Bos taurus Protein: ALOX5AP
Summary
InnateDB Protein IDBP-681978.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ALOX5AP
Protein Name Arachidonate 5-lipoxygenase-activating protein
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000017570
InnateDB Gene IDBG-630519 (ALOX5AP)
Protein Structure
UniProt Annotation
Function Required for leukotriene biosynthesis by ALOX5 (5- lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes (By similarity). unstructured (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008047 enzyme activator activity
GO:0047485 protein N-terminus binding
GO:0050544 arachidonic acid binding
Biological Process
GO:0002540 leukotriene production involved in inflammatory response
GO:0006691 leukotriene metabolic process
GO:0019370 leukotriene biosynthetic process
GO:0043085 positive regulation of catalytic activity
GO:0070207 protein homotrimerization
GO:0071277 cellular response to calcium ion
Cellular Component
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031965 nuclear membrane
Protein Structure and Domains
PDB ID
InterPro IPR001129 Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein
IPR001446 5-lipoxygenase-activating protein
PFAM PF01124
PRINTS PR00488
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q148F2
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 613869
UniGene
RefSeq NP_001069761
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC118389
GenPept AAI18390

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca