Version 5.4
Bos taurus Protein: GJA1
Summary
InnateDB Protein IDBP-682048.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GJA1
Protein Name Gap junction alpha-1 protein
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000002398
InnateDB Gene IDBG-630590 (GJA1)
Protein Structure
UniProt Annotation
Function Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.
Predicted by orthology
Total 30 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005102 receptor binding
GO:0005243 gap junction channel activity
GO:0005515 protein binding
GO:0017124 SH3 domain binding
GO:0022857 transmembrane transporter activity
GO:0030165 PDZ domain binding
GO:0048487 beta-tubulin binding
GO:0097110 scaffold protein binding
Biological Process
GO:0001649 osteoblast differentiation
GO:0001701 in utero embryonic development
GO:0001764 neuron migration
GO:0001947 heart looping
GO:0002070 epithelial cell maturation
GO:0002088 lens development in camera-type eye
GO:0003294 atrial ventricular junction remodeling
GO:0007154 cell communication
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0007507 heart development
GO:0007512 adult heart development
GO:0008016 regulation of heart contraction
GO:0008285 negative regulation of cell proliferation
GO:0009268 response to pH
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010643 cell communication by chemical coupling
GO:0010644 cell communication by electrical coupling
GO:0015867 ATP transport
GO:0030500 regulation of bone mineralization
GO:0035050 embryonic heart tube development
GO:0042733 embryonic digit morphogenesis
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043403 skeletal muscle tissue regeneration
GO:0045216 cell-cell junction organization
GO:0045732 positive regulation of protein catabolic process
GO:0045844 positive regulation of striated muscle tissue development
GO:0046850 regulation of bone remodeling
GO:0048514 blood vessel morphogenesis
GO:0048812 neuron projection morphogenesis
GO:0051259 protein oligomerization
GO:0055085 transmembrane transport
GO:0060156 milk ejection
GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization
GO:0060371 regulation of atrial cardiac muscle cell membrane depolarization
GO:0060373 regulation of ventricular cardiac muscle cell membrane depolarization
GO:0061337 cardiac conduction
Cellular Component
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005771 multivesicular body
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005882 intermediate filament
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005916 fascia adherens
GO:0005921 gap junction
GO:0005922 connexon complex
GO:0014704 intercalated disc
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0016328 lateral plasma membrane
GO:0030054 cell junction
GO:0043292 contractile fiber
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000500 Connexin
IPR002261 Gap junction alpha-1 protein (Cx43)
IPR013092 Connexin, N-terminal
IPR013124 Gap junction alpha-1 protein (Cx43), C-terminal
IPR019570 Gap junction protein, cysteine-rich domain
PFAM PF00029
PF03508
PF10582
PRINTS PR00206
PR01132
PIRSF
SMART SM00037
SM01089
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P18246
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 281193
UniGene Bt.69926
RefSeq NP_776493
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC105464 J05535
GenPept AAA30459 AAI05465

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca