Version 5.4
Bos taurus Protein: PEX19
Summary
InnateDB Protein IDBP-682067.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PEX19
Protein Name Peroxisomal biogenesis factor 19
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000009921
InnateDB Gene IDBG-630601 (PEX19)
Protein Structure
UniProt Annotation
Function Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53 (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Peroxisome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Mainly cytoplasmic. Some fraction membrane- associated to the outer surface of peroxisomes. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.
Predicted by orthology
Total 35 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0036105 peroxisome membrane class-1 targeting sequence binding
GO:0047485 protein N-terminus binding
GO:0051117 ATPase binding
Biological Process
GO:0006625 protein targeting to peroxisome
GO:0007031 peroxisome organization
GO:0016557 peroxisome membrane biogenesis
GO:0016559 peroxisome fission
GO:0045046 protein import into peroxisome membrane
GO:0050821 protein stabilization
GO:0061077 chaperone-mediated protein folding
GO:0072321 chaperone-mediated protein transport
GO:0072663 establishment of protein localization to peroxisome
GO:1900131 negative regulation of lipid binding
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005777 peroxisome
GO:0005778 peroxisomal membrane
GO:0005829 cytosol
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0043234 protein complex
Protein Structure and Domains
PDB ID
InterPro IPR006708 Pex19 protein
PFAM PF04614
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3SZD1
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 521522
UniGene Bt.46094
RefSeq NP_001029712
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC102949
GenPept AAI02950

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca