InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: ACSF3

Summary

InnateDB Protein

IDBP-682162.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACSF3

Protein Name

Acyl-CoA synthetase family member 3, mitochondrial

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000021234

InnateDB Gene

IDBG-630685 (ACSF3)

Protein Structure

UniProt Annotation

Function

Catalyzes the initial reaction in intramitochondrial fatty acid synthesis, by activating malonate and methylmalonate, but not acetate, into their respective CoA thioester. May have some preference toward very-long-chain substrates (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003824	catalytic activity
GO:0005524	ATP binding
GO:0016874	ligase activity
GO:0016878	acid-thiol ligase activity
GO:0090409	malonyl-CoA synthetase activity

Biological Process

GO:0006629	lipid metabolic process
GO:0006631	fatty acid metabolic process
GO:0006633	fatty acid biosynthetic process
GO:0008152	metabolic process
GO:0090410	malonate catabolic process

Cellular Component

GO:0005739

mitochondrion

Protein Structure and Domains

PDB ID

InterPro

IPR000873 AMP-dependent synthetase/ligase

PFAM

PF00501

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q58DN7

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

509209

UniGene

Bt.49591

RefSeq

NP_001030240

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC102586 BT021560

GenPept

AAI02587 AAX46407