InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: APOBEC2

Summary

InnateDB Protein

IDBP-682266.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

APOBEC2

Protein Name

Probable C->U-editing enzyme APOBEC-2

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000035907

InnateDB Gene

IDBG-630779 (APOBEC2)

Protein Structure

UniProt Annotation

Function

Probable C to U editing enzyme whose physiological substrate is not yet known. Does not display detectable apoB mRNA editing. Has a low intrinsic cytidine deaminase activity. May play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0008270	zinc ion binding
GO:0016787	hydrolase activity
GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
GO:0046872	metal ion binding

Biological Process

GO:0006397	mRNA processing
GO:0016556	mRNA modification
GO:0080111	DNA demethylation

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR007904 APOBEC-like, C-terminal
IPR013158 APOBEC-like, N-terminal
IPR016193 Cytidine deaminase-like

PFAM

PF05240
PF08210

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q3SYR3

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

509619

UniGene

RefSeq

NP_001029527

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC103438 DQ280381

GenPept

AAI03439 ABB90107