Version 5.4
Bos taurus Protein: ZDHHC21
Summary
InnateDB Protein IDBP-682270.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZDHHC21
Protein Name Probable palmitoyltransferase ZDHHC21
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000008139
InnateDB Gene IDBG-630784 (ZDHHC21)
Protein Structure
UniProt Annotation
Function Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptor (By similarity). {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Golgi apparatus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0008270 zinc ion binding
GO:0016409 palmitoyltransferase activity
GO:0016740 transferase activity
GO:0016746 transferase activity, transferring acyl groups
GO:0019706 protein-cysteine S-palmitoyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0001942 hair follicle development
GO:0018230 peptidyl-L-cysteine S-palmitoylation
GO:0018345 protein palmitoylation
GO:0048733 sebaceous gland development
Cellular Component
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR001594 Zinc finger, DHHC-type, palmitoyltransferase
PFAM PF01529
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A2VDT6
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 535814
UniGene Bt.52087
RefSeq NP_001075003
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC133395
GenPept AAI33396

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca