Version 5.4
Bos taurus Protein: DPEP1
Summary
InnateDB Protein IDBP-682337.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DPEP1
Protein Name Dipeptidase 1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000016201
InnateDB Gene IDBG-630851 (DPEP1)
Protein Structure
UniProt Annotation
Function Hydrolyzes a wide range of dipeptides. Implicated in the renal metabolism of glutathione and its conjugates. Converts leukotriene D4 to leukotriene E4; it may play an important role in the regulation of leukotriene activity (By similarity). {ECO:0000250}.
Subcellular Localization Apical cell membrane {ECO:0000250}; Lipid- anchor, GPI-anchor {ECO:0000250}. Note=Brush border membrane. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008235 metalloexopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008239 dipeptidyl-peptidase activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0016805 dipeptidase activity
GO:0034235 GPI anchor binding
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0046872 metal ion binding
GO:0070573 metallodipeptidase activity
GO:0072341 modified amino acid binding
Biological Process
GO:0006508 proteolysis
GO:0016999 antibiotic metabolic process
GO:0030336 negative regulation of cell migration
GO:0035690 cellular response to drug
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0050667 homocysteine metabolic process
GO:0071277 cellular response to calcium ion
GO:0071732 cellular response to nitric oxide
Cellular Component
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0031225 anchored component of membrane
GO:0045177 apical part of cell
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR008257 Renal dipeptidase family
PFAM PF01244
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3SZM7
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 514685
UniGene Bt.48813
RefSeq NP_001029644
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC102783
GenPept AAI02784

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca