Bos taurus Protein: POLR3A
Summary
InnateDB Protein IDBP-682369.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol POLR3A
Protein Name DNA-directed RNA polymerase III subunit RPC1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000017638
InnateDB Gene IDBG-630873 (POLR3A)
Protein Structure
UniProt Annotation
Function DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001056 RNA polymerase III activity
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003899 DNA-directed RNA polymerase activity
GO:0008270 zinc ion binding
GO:0016740 transferase activity
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0046872 metal ion binding
Biological Process
GO:0002376 immune system process
GO:0006351 transcription, DNA-templated
GO:0006383 transcription from RNA polymerase III promoter
GO:0032728 positive regulation of interferon-beta production
GO:0045087 innate immune response
GO:0051607 defense response to virus
Cellular Component
GO:0005634 nucleus
GO:0005666 DNA-directed RNA polymerase III complex
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR000722 RNA polymerase, alpha subunit
IPR006592 RNA polymerase, N-terminal
IPR007066 RNA polymerase Rpb1, domain 3
IPR007080 RNA polymerase Rpb1, domain 1
IPR007081 RNA polymerase Rpb1, domain 5
IPR007083 RNA polymerase Rpb1, domain 4
PFAM PF00623
PF04983
PF04997
PF04998
PF05000
PRINTS
PIRSF
SMART SM00663
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A4IF62
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 540308
UniGene Bt.58772
RefSeq NP_001077219
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC134422
GenPept AAI34423