Bos taurus Protein: POLR3A | |||||||||||||||||||||
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Summary | |||||||||||||||||||||
InnateDB Protein | IDBP-682369.2 | ||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||
Gene Symbol | POLR3A | ||||||||||||||||||||
Protein Name | DNA-directed RNA polymerase III subunit RPC1 | ||||||||||||||||||||
Synonyms | |||||||||||||||||||||
Species | Bos taurus | ||||||||||||||||||||
Ensembl Protein | ENSBTAP00000017638 | ||||||||||||||||||||
InnateDB Gene | IDBG-630873 (POLR3A) | ||||||||||||||||||||
Protein Structure | |||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||
Function | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity). {ECO:0000250}. | ||||||||||||||||||||
Subcellular Localization | Nucleus {ECO:0000250}. | ||||||||||||||||||||
Disease Associations | |||||||||||||||||||||
Tissue Specificity | |||||||||||||||||||||
Comments | |||||||||||||||||||||
Interactions | |||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||
PDB ID | |||||||||||||||||||||
InterPro |
IPR000722
RNA polymerase, alpha subunit IPR006592 RNA polymerase, N-terminal IPR007066 RNA polymerase Rpb1, domain 3 IPR007080 RNA polymerase Rpb1, domain 1 IPR007081 RNA polymerase Rpb1, domain 5 IPR007083 RNA polymerase Rpb1, domain 4 |
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PFAM |
PF00623
PF04983 PF04997 PF04998 PF05000 |
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PRINTS | |||||||||||||||||||||
PIRSF | |||||||||||||||||||||
SMART |
SM00663
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TIGRFAMs | |||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||
Modification | |||||||||||||||||||||
Cross-References | |||||||||||||||||||||
SwissProt | A4IF62 | ||||||||||||||||||||
PhosphoSite | PhosphoSite- | ||||||||||||||||||||
TrEMBL | |||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||
Entrez Gene | 540308 | ||||||||||||||||||||
UniGene | Bt.58772 | ||||||||||||||||||||
RefSeq | NP_001077219 | ||||||||||||||||||||
HUGO | |||||||||||||||||||||
OMIM | |||||||||||||||||||||
CCDS | |||||||||||||||||||||
HPRD | |||||||||||||||||||||
IMGT | |||||||||||||||||||||
EMBL | BC134422 | ||||||||||||||||||||
GenPept | AAI34423 | ||||||||||||||||||||