InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: DROSHA

Summary

InnateDB Protein

IDBP-682459.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DROSHA

Protein Name

drosha, ribonuclease type III

Synonyms

RNASEN;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000023346

InnateDB Gene

IDBG-630832 (DROSHA)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001530	lipopolysaccharide binding
GO:0003723	RNA binding
GO:0004521	endoribonuclease activity
GO:0004525	ribonuclease III activity
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006396	RNA processing
GO:0010468	regulation of gene expression
GO:0010586	miRNA metabolic process
GO:0016075	rRNA catabolic process
GO:0031053	primary miRNA processing
GO:0031054	pre-miRNA processing
GO:0050829	defense response to Gram-negative bacterium
GO:0050830	defense response to Gram-positive bacterium
GO:0090501	RNA phosphodiester bond hydrolysis
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR000999 Ribonuclease III domain
IPR014720 Double-stranded RNA-binding domain

PFAM

PF00636
PF14622
PF00035

PRINTS

PIRSF

SMART

SM00535
SM00358

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

E1BGY0

UniProt Splice Variant

Entrez Gene

540168

UniGene

RefSeq

XP_005196242

HUGO

HGNC:17904

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02050706

GenPept