InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: FAM213A

Summary

InnateDB Protein

IDBP-682645.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FAM213A

Protein Name

UPF0765 protein C10orf58 homolog

Synonyms

C10orf58; C28H10orf58; PAMM;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000028551

InnateDB Gene

IDBG-631138 (FAM213A)

Protein Structure

UniProt Annotation

Function

Involved in redox regulation of the cell. Acts as an antioxidant. Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation. May affect bone resorption and help to maintain bone mass (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016209	antioxidant activity
GO:0016491	oxidoreductase activity

Biological Process

GO:0045670	regulation of osteoclast differentiation
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000866 Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
IPR012336 Thioredoxin-like fold

PFAM

PF00578
PF13098
PF13192
PF13462
PF13905

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q3ZBK2

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

534049

UniGene

Bt.49409

RefSeq

NP_001029771

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC103249

GenPept

AAI03250