InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: HGF

Summary

InnateDB Protein

IDBP-682711.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HGF

Protein Name

hepatocyte growth factor precursor

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000023490

InnateDB Gene

IDBG-631194 (HGF)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0042056	chemoattractant activity
GO:0042802	identical protein binding

Biological Process

GO:0000187	activation of MAPK activity
GO:0000902	cell morphogenesis
GO:0001889	liver development
GO:0006508	proteolysis
GO:0008283	cell proliferation
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0030335	positive regulation of cell migration
GO:0035729	cellular response to hepatocyte growth factor stimulus
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0048012	hepatocyte growth factor receptor signaling pathway
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050918	positive chemotaxis
GO:0051450	myoblast proliferation
GO:0060326	cell chemotaxis
GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
GO:0090201	negative regulation of release of cytochrome c from mitochondria
GO:1901299	negative regulation of hydrogen peroxide-mediated programmed cell death
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000573	positive regulation of DNA biosynthetic process

Cellular Component

GO:0016020

membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000001 Kringle
IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR003014 PAN-1 domain
IPR003609 Apple-like
IPR009003 Trypsin-like cysteine/serine peptidase domain
IPR013806 Kringle-like fold

PFAM

PF00051
PF00089
PF00024

PRINTS

PR00722

PIRSF

SMART

SM00130
SM00020
SM00473

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

Q9BGN9

UniProt Splice Variant

Entrez Gene

282879

UniGene

Bt.13085

RefSeq

NP_001026921

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AB056447 DAAA02010377 DAAA02010378 DAAA02010379 DAAA02010380

GenPept

BAB33031