InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: NF1

Summary

InnateDB Protein

IDBP-682892.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NF1

Protein Name

neurofibromin 1

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000015699

InnateDB Gene

IDBG-631285 (NF1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.

Predicted by orthology
Total	24 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0005099	Ras GTPase activator activity
GO:0005488	binding
GO:0005515	protein binding
GO:0008429	phosphatidylethanolamine binding
GO:0031210	phosphatidylcholine binding

Biological Process

GO:0000165	MAPK cascade
GO:0001649	osteoblast differentiation
GO:0001656	metanephros development
GO:0001666	response to hypoxia
GO:0001889	liver development
GO:0001937	negative regulation of endothelial cell proliferation
GO:0001938	positive regulation of endothelial cell proliferation
GO:0001952	regulation of cell-matrix adhesion
GO:0001953	negative regulation of cell-matrix adhesion
GO:0006469	negative regulation of protein kinase activity
GO:0007154	cell communication
GO:0007165	signal transduction
GO:0007265	Ras protein signal transduction
GO:0007406	negative regulation of neuroblast proliferation
GO:0007420	brain development
GO:0007422	peripheral nervous system development
GO:0007507	heart development
GO:0007519	skeletal muscle tissue development
GO:0008285	negative regulation of cell proliferation
GO:0008542	visual learning
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
GO:0014044	Schwann cell development
GO:0014065	phosphatidylinositol 3-kinase signaling
GO:0016525	negative regulation of angiogenesis
GO:0021510	spinal cord development
GO:0021897	forebrain astrocyte development
GO:0021915	neural tube development
GO:0021987	cerebral cortex development
GO:0022011	myelination in peripheral nervous system
GO:0030036	actin cytoskeleton organization
GO:0030198	extracellular matrix organization
GO:0030199	collagen fibril organization
GO:0030325	adrenal gland development
GO:0030336	negative regulation of cell migration
GO:0032228	regulation of synaptic transmission, GABAergic
GO:0032318	regulation of Ras GTPase activity
GO:0032320	positive regulation of Ras GTPase activity
GO:0035021	negative regulation of Rac protein signal transduction
GO:0042060	wound healing
GO:0042127	regulation of cell proliferation
GO:0042992	negative regulation of transcription factor import into nucleus
GO:0043065	positive regulation of apoptotic process
GO:0043407	negative regulation of MAP kinase activity
GO:0043409	negative regulation of MAPK cascade
GO:0043473	pigmentation
GO:0043525	positive regulation of neuron apoptotic process
GO:0043535	regulation of blood vessel endothelial cell migration
GO:0045124	regulation of bone resorption
GO:0045671	negative regulation of osteoclast differentiation
GO:0045685	regulation of glial cell differentiation
GO:0045762	positive regulation of adenylate cyclase activity
GO:0045765	regulation of angiogenesis
GO:0046580	negative regulation of Ras protein signal transduction
GO:0046929	negative regulation of neurotransmitter secretion
GO:0048147	negative regulation of fibroblast proliferation
GO:0048169	regulation of long-term neuronal synaptic plasticity
GO:0048485	sympathetic nervous system development
GO:0048593	camera-type eye morphogenesis
GO:0048712	negative regulation of astrocyte differentiation
GO:0048715	negative regulation of oligodendrocyte differentiation
GO:0048745	smooth muscle tissue development
GO:0048844	artery morphogenesis
GO:0048853	forebrain morphogenesis
GO:0050890	cognition
GO:0051056	regulation of small GTPase mediated signal transduction
GO:1902043	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2001241	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand